Tests — at-home + lab order

Run cheap at-home tests first → lab spend gated on which fire. Full lab list = print-ready for GP visit 2026-06-10.
0 / 0 done Total cost if all run: €0 Sequence: Packet A (high-confidence) → Packet B (supporting) → Packet C (Bart falsifiers)

Packet A — high confidence, do first

Test 1 — Urine-in-sunlight (AIP falsifier) ✅ 2× CLEAN 2026-05-22
Patient ran 2× non-fasted home test. Zero darkening + clean smell. AIP dropped from ~7% prior to <2%. Formal PBG/ALA lab no longer needed.
€0
Test 5 — L-citrulline 3g + beetroot juice 250ml at altitude headache onset endothelial-NO ⭐
Drive to 1200m Schwarzwald. At headache onset: 3g L-citrulline + 250ml beetroot. Log resolution time vs. historical "days" baseline. Resolution ≤2h = endothelial-NO bottleneck confirmed → triggers Galaxy Bart ePCR lab.
€15
Test 7 — Ice cube + dermographism paired skin test ✅ NEGATIVE 2026-05-21
Cold urticaria ruled out. Dermographism negative = MCAS is perivascular, not skin-resident.
€0
Test 8 — Niacin 100mg flush response methylation
100mg plain niacin (not niacinamide) AM empty stomach. Watch 30 min. ABSENT/MINIMAL flush = schizophrenia-spectrum / EFA deficiency marker (brother-relevant). INTENSE rapid = mast-cell + methylation issue. Densest €5 diagnostic in the battery.
€5

Packet B — supporting

Test 4 — L-tyrosine 1.5g (Toxo discriminator)
Day A: 1.5g L-tyrosine on rising. Count loops + Bart-laugh frequency 10-min windows for 3h. Day B (7 days later): 1.5g L-leucine control, identical day. Higher counts on tyrosine = Toxo basal-ganglia plausible.
€10
Test 9 — NASA Lean + salt-loading day comparison POTS phenotyping
Day A: NASA Lean (back against wall, feet 6in out). HR + symptoms at 1/5/10 min. Day B: same test next AM but pre-loaded with 1L water + 2g salt 90 min before. Improvement Day B = hyperadrenergic POTS (salt-responsive). Minimal change = neuropathic (different drug choice).
€0
Test 2 — Vibration test 10 min on running washer HαT
Sit/stand against running washer high spin 10 min. Schellong before + 0/30/60 min after. Log flush, airway tightness, sticky-thought count.
€0
Test 3 — 41°C hot bath 15 min, no AM cetirizine HαT
Sunday AM empty stomach. Schellong before + after. Triangulation with Test 2 via different stimulus.
€0

Packet C — Bart-primary falsifiers (Council R7 ⭐)

Test 10 — Nailfold capillaroscopy R7 NEW
What: Bart uniquely colonizes endothelial cells. Nailfold capillaries are the easiest to inspect visually. Microhemorrhages / tortuous loops / avascular zones = active Bart vasculopathy. Normal parallel hairpin loops = downgrade Bart.
Protocol: (1) Smartphone macro lens 10-20× OR microscope. (2) Drop of mineral oil on cuticle. (3) Bright LED from the side. (4) Image distal nailfold of 5 fingers each hand = 10 images. (5) Repeat next day.
Read: All 10 normal × 2 days = downgrade Bart-primary. Abnormal = strengthen. Bonus: Save images for pre/post-treatment comparison (kill-protocol progress marker).
€0-15
Test 11 — Serum VEGF R7 NEW
What: Bart's pathognomonic mechanism is forcing endothelial cells to secrete VEGF → drives angiogenesis. Active Bart = elevated VEGF.
Where: Via GP June 10 panel, or direct-pay lab (Imugen, ArminLabs, local). Single blood draw, fasted or non-fasted both OK.
Read: Low/rock-bottom = downgrade Bart-primary substantially (pivot to autoimmune amplifier or CSTC primary). Elevated/high-normal = strengthen Bart.
€40-80
Test 12 — Pre-MB baseline LFT + CBC + platelets R7 NEW
What: ALT/AST/GGT/ALP/bilirubin + CMP + CBC w/platelets + creatinine/eGFR. Safety anchor BEFORE MB launches.
Why now: Polyphenol + herb load is real. Need "known good" baseline to compare any 4-week recheck against.
When: Add to June 10 GP panel, OR walk-in lab 5/24-5/25.
Read: Within range = GO MB. >2× ULN ALT/AST = HOLD MB.
€20-40

Optional

Test 6 — Cervical traction + hard collar 4h during head-pressure flare CCI
Gemini's contrarian. Acquire hard collar (~€30) or partner manual traction 5 min lying supine. Full protocol on /cervical-test.
€30

Packet D — Extended battery (R5 expansion, low-hanging fruits)

Test D1 — HRV morning baseline (smartphone) vagal tone
Lying down, first 90s after waking, before standing. 7-day baseline (HRV4Training / Welltory / Elite HRV). RMSSD <30ms for age 35 = sympathetic dominance. Rises ≥20% with cetirizine washout = histamine-driven sympathetic load. One number means nothing — need 7d baseline.
€0
Test D2 — Breath-hold BOLT CO2 tolerance hypoxia / vagal
Sit 5min calm. Normal exhale → pinch nose → count seconds to FIRST urge to breathe (not max hold). 3 trials, median. <20s = poor; 20-40s = ok; >40s = good. Re-measure post L-citrulline 6g AM — improvement = endothelial-NO-limited.
€0
Test D3 — L-theanine 200mg challenge glutamate / GABA
200mg empty stomach AM isolated. Rate corrugator + sticky-thoughts + standing HR at 0, 45min, 2h, 4h. Clear corrugator relax + sticky-thought drop at 45-90min = high glutamate tone / PANS-relevant axis.
€3
Test D4 — Salt loading responder (paired with Test 9 NASA Lean) POTS phenotyping
Morning standing HR baseline. Then 2g NaCl (½ tsp) in 500ml water. Re-measure standing HR at 30, 60, 90 min. Rate sticky-thoughts. Drops ≥10bpm + clarity rises = salt/volume responder POTS phenotype. Skip if BP elevated.
€1
Test D5 — Cetirizine washout (24h skip) H1 axis decomp
Skip cetirizine 24h on non-kill non-test day. Log which axes return + ETA after last dose. Sticky-thoughts return at h12-18 = H1-buffered PANS axis. HR/POTS returns = H1-buffered endothelial. Skin only = pure cutaneous MCAS. Don't washout during flare or kill day; have loratadine backup.
€0
Test D6 — Amsler grid (retinal — PEX / Toxo) eye / Toxo
Print Amsler grid, 30cm from face, ONE eye at a time, fixate center dot. Note wavy lines, missing squares, gray patches. R-eye especially (VCS asymmetry). Re-test monthly. Persistent defect = book Augenarzt. LOXL1 10× makes baseline mandatory.
€0
Test D7 — Overnight pulse-ox (3 nights) UARS / nocturnal hypoxia
Wear €15-20 Wellue O2Ring or similar finger-clip overnight × 3 nights. Read curve in app. Mean SpO2 <94%, dips <88%, or ODI >5/hr = abnormal → ENT/sleep referral. Single bad night not diagnostic; need pattern. Relevant given scalloped tongue + photic somnolence + HNO sleep test pending.
€15-20
Test D8 — Glucose tolerance felt-effect (50g dextrose) AIP / reactive hypo
50g pure dextrose in water on empty AM stomach. Log standing HR + sticky-thoughts + corrugator + skin warmth at 0, 30, 60, 90, 120, 180 min. AIP+: clear relief at 30-60 if mid-flare. Reactive hypo: crash + sticky thoughts + irritability at 90-120 min. (AIP already 2× clean on home porphyrin — this is supplementary.)
€3
Test D9 — Bromelain 500mg solo microclot / mast cell
500mg empty stomach AM isolated. Rate brain fog + calf heaviness + post-meal sleepiness for next 6h. Clearer head + lighter calves + less post-meal slump 1-3h = microclot/fibrin-burden relief. Not with anticoagulants beyond aspirin microdose (monitor bruising).
€5
Test D10 — Aged cheese / fermented sausage bolus (no DAOSiN) HαT
Single histamine bolus + tryptase release test. Sticky-thoughts spike, flush, throat, GI symptoms within hours = HαT-spectrum. Already informative if cascade pattern echoes the yoghurt 4-phase. Stop with DAOSiN if symptoms strong.
€5
Test D11 — NSAID test (single ibuprofen 400mg) HαT
NSAID-induced mast-cell flare in HαT subset. Sticky-thought + flush worsening within 2-4h = HαT-suspicious. Don't combine with aspirin holding period; OTC route.
€2
Test D12 — Forward-head / cervical retraction (CCI provocation) CCI
Forward-head 10 min (chin jutted, phone-look). Log symptoms. Then chin-tuck retraction 10 min (chin back, occiput tall). Log delta. Forward-head provokes brain fog/nausea/HR + retraction relieves = CCI flavor. (Also see full /cervical-test protocol.)
€0
Test D13 — Cervical lymph palpation + Stemmer sign R9 lymphatic axis
Supine, head 45° contralateral. Palpate SCM + supraclavicular fossae + posterior triangle. Map rubbery 3-8mm nodes. Stemmer: pinch-and-lift skinfold on toe webs + 2nd/3rd finger webs — doesn't tent normally = early lymphedema. Counterpart: sternal pinch over manubrium vs lateral clavicle — asymmetric thickening = ipsilateral lymph congestion. Shoulder/scapula spider cluster sits over the supraclav drainage field — this is the R9 lateral test.
€0
Test D14 — Schirmer dry-eye (Sjögren screen) R10 alternative
Coffee-filter strip cut to 5×35mm, 5min in lower lid bilaterally. <5mm wetting both eyes + photophobia + dry mouth = Sjögren-spectrum. Your chronic red eyes might be sicca, not pure Bart-conjunctival-injection. R10 steelman discriminator.
€0
Trigger map for lab escalation:
0 / 0 selected Sum if all selected: €0 Bring printed list + signal IGeL-Bereitschaft at GP visit
📋 Bring zum Hausarzt-Termin 2026-06-10 (NÜCHTERN!):

T1 Stealth-Pathogene (Co-Infektionen)

Bartonella henselae IgG + IgM
HÖCHSTE Vortest-Wahrscheinlichkeit. Großmutter jahrzehntelang viele Katzen + Flohbefall. Kindheits-Ausschläge retroskopisch als Flohbisse erkennbar. Photophobie + Cherry-Angiome + Striae + mood lability = Bart-typisch.
€55
Borrelia burgdorferi IgG + IgM (+ Western Blot Reflex)
Schwarzwald = Endemiegebiet. Knieschmerz Onset mit 19 + lebenslange Laufbeschränkung. SI-Loosening unter Crypto/Andro. Bruder hatte 2 unbehandelte Zeckenstiche. Bei positivem ELISA → unbedingt Western Blot anfordern.
€50
Babesia microti IgG + IgM
Erklärt historische Nachtschweiß-Phase (frühe 20er) + chronischen Atemhunger + Höhen-Kopfschmerzen. Klassischer Co-Infektionspartner. Erfordert anti-malarische Therapie, die das Buhner-Stack NICHT abdeckt.
€25
Mycoplasma pneumoniae IgG + IgM
Crypto/Andro/Psilo konvergieren auf Atemwege ("endlich frei atmen"). Chronische Rhinitis ≥15 Jahre.
€25
EBV-Reaktivierung Panel (EA-D + EBNA + VCA IgG/IgM)
Gürtelrose mit ~6 = Frühzeichen viraler Reaktivierungs-Tendenz. EBV-Reaktivierung häufiger Treiber von ME/CFS/MCAS.
€35

T1 Objektive Marker + R7 Bart-falsifier

Serum VEGF R7
Bart-angiogenesis biochemistry. Elevated = strengthens Bart-primary. Low/rock-bottom = pivot to autoimmune amplifier or CSTC primary.
€40-80
Serum-Tryptase (baseline)
Objektiver MCAS-Biomarker. >11.4 ng/mL = MCAS-leaning. Anchors mast-cell hypothesis objectively.
€50
hs-CRP (hochsensitives)
Chronische niedriggradige Entzündung. Baseline für Stealth-Protokoll.
€20
Großes Blutbild + Differential (CBC)
Eosinophile + Basophile + Lymphozyten-Atypien. Häufig Kassen-gedeckt.
€20
Leberwerte ALT/AST/GGT R7 Pre-MB anchor
MANDATORY pre-MB baseline (R7). Polyphenol + herb load + future MB = real hepatic load. Compare any 4-week recheck against this.
€15

T1 Eisen / Energie / Nährstoffe

Ferritin
Eisenreserve. Niedrig → Müdigkeit + MCAS-verstärkend. Gemeinsam mit hs-CRP interpretieren.
€20
Eisen + Transferrin + TSAT
Vollständiges Eisenbild. Ferritin allein verfehlt Utilisationsstörungen.
€35
25(OH)-Vitamin D
VDR all-variant + CYP2R1 reduced + sun avoidance → wahrscheinlich niedrig trotz 5000 IU/d. Target: 60-80 ng/mL.
€35
HbA1c
3-Monats-BZ. Wegen "Zucker-Binge → krank" Pattern.
€20

T2 Hormone + Schilddrüse + Mikronährstoffe

TSH + freies T3 + freies T4
Subklinische Hypothyreose überlappt mit photic-Hypersomnolenz. TSH meist Kasse, fT3/fT4 oft IGeL.
€45
Calcitonin ⭐ KASSE-DEFENSIBLE
Großvater hatte Schilddrüsenkrebs = direkter ICD-10 Familien-Anchor. RET-Risiko + 2 cancer-Risiko-Varianten. Wenn GP Calcitonin verweigert → GP wechseln.
€40
Testosteron gesamt + frei + SHBG
Cetirizin flachte Libido-Hyperarousal dramatisch ab. Baseline klärt ob hoch (echter Testo-Treiber) oder mastzellgetrieben.
€40
Holotranscobalamin (aktives B12)
Relevanter als Gesamt-B12 für zelluläre Verfügbarkeit. Brain fog / Fatigue / Faszikulationen.
€50
Zink (Serum)
Chronische Seborrhö seit 19 + Hautbarriere-Dysfunktion. Zinkmangel imitiert MCAS + treibt Seborrhö.
€15

T2 Autoimmun (HLA-B27 Cluster)

HLA-B27 Typisierung
Promethease zeigt Tag-Variante; HLA-B27-positiv ist starkes Argument für SpA/Bechterew + erhöhtes Bart-reactive-arthritis Risiko.
€60
anti-CCP + Rheumafaktor
5,2× RA-Risiko Promethease. Frühe RA-Marker bei Verdacht auf entzündlich-rheumatische Erkrankung.
€30
ANA (Antinukleäre Antikörper)
Breiter Autoimmun-Screen. Bei negativem Ergebnis hilfreich zum Ausschluss klassischer AI-Diagnosen.
€40

T3 Optional / Nice-to-have

Chlamydia pneumoniae IgG + IgM
Schwester-Pathogen zu Mycoplasma, ähnliches Profil. Nur falls Hausarzt mitspielt.
€25
C3 / C4 Komplement
Komplement-Verbrauch bei Autoimmun + bei chronischen intrazellulären Infektionen.
€40
Lp(a) + ApoB + Lipidpanel
Cardiovascular risk + NOS3-Kontext. Lp(a) ist Lifetime-Marker (einmal messen).
€50
⚠️ Wenn etwas verweigert wird:
Hinweise:

Sources: personal/kasse-igel-justification-2026-05-21.md · Council R7 falsifiers: personal/_archive/council-2026-05-22-round7-stack-pre-mb-launch/